Assessing Irregular Heart Rhythm as a Risk for Stroke and Dementia

One in twenty people aged over 65 has an irregular heart rhythm, called atrial fibrillation. People with atrial fibrillation are at increased risk of having strokes. They may also be more likely to suffer ‘mini-strokes’, which could cause memory problems and dementia.

The aim of this study is to find out if older people with atrial fibrillation are at increased risk of memory problems and whether their memory deteriorates more quickly over time. Treating people with atrial fibrillation using blood thinning drugs such as warfarin and aspirin can reduce their risk of having a stroke. The researchers hope to find out if this treatment also decreases their chances of developing memory problems.

The initial part of the study has already been completed, involving 362 older people (174 with atrial fibrillation and 188 with a normal heart rhythm). These participants undertook detailed memory tests at the start of the study, and again twelve months later.

The researchers now want to visit the study participants again three years after their first assessment, to repeat their memory tests. The team feel that this extra visit could be very important, as any changes in memory in people with atrial fibrillation will probably continue to develop over time. The study may confirm that atrial fibrillation is an important risk factor for dementia due to small strokes. It may also show that treatment with blood thinning tablets protects against memory problems in older people with atrial fibrillation, as well as reducing the risk of stroke.

Scientific Title: Cognition in Atrial Fibrillation Evaluation: Follow up Study

Classification:
Prevention, Neuroprotection/Clinical Psychology

Publications:

Park H, Hildreth A, Thomson R, O'Connell J. Non-valvular atrial fibrillation and cognitive function - baseline results of a longitudinal cohort study. Age and Ageing 2005 Jul;34(4):392-5

Park H, O'Connell J, Thomson R. A systematic review of cognitive decline in the general elderly population. International Journal of Geriatric Psychiatry. 2003;18:1121-1134.

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