Assessing which drug therapy is best at reducing blood clots and preventing recurrent stroke

In the first few weeks after a TIA or minor stroke there is a very high risk of recurrent stroke. Aspirin alone fails to prevent many of these recurrent strokes, and the best drug therapy to prevent them is not known. This study will compare two drug therapy regimens, clopidogrel or dipyridamole, given to patients in addition to aspirin. The researchers will assess the effectiveness of each drug by examining which one can reduce asymptomatic emboli (blood clots) the most. The asymptomatic emboli will be detected using a novel ambulatory ultrasound system, which allows the researchers to record for up to eight hours while the person is walking around. The results will help determine the best method to prevent recurrent stroke in this situation.

Scientific Title: Dual antiplatelet therapy in the acute phase following stroke and TIA; which is the best regimen?

Classification:
Clinical Pharmacology, Prevention

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