Investigation of Risk Factors for Stroke in Women and Older People

Most strokes occur in men and women at older ages. To prevent strokes from occurring it is important to understand the causes in different groups of people. There is a lack of information about the effects of various risk factors on the health of women and older people in particular. This large community based study will identify the lifestyle factors, such as diet and physical activity, that may protect against stroke; with the aim of understanding how they affect the biological processes, such as blood pressure, that lead to stroke. This study, which is part of a nine country European study, may also lead to an explanation of the reasons for large variations in stroke rates between different European countries; as well as by social class in this country. Ultimately this will lead to the development of effective prevention programmes.

Scientific Title: Determinants and prevention of stroke: a prospective cohort study including women and older persons

PowerPoint presentation of this research project (476 kb)

This presentation was presented by the researchers at The Stroke Association Scientific Conference in September 2005.

Classification:
Prevention, Information, education

Publications:

Sinha S, Luben R, Welch A, Bingham S, Wareham N, Day N, Khaw K. Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population. Eur J Cardiovasc Prev Rehab 2005;12:144-50.

Yuyun M, Khaw K, Luben R, Welch A, Bingham S, Day N, Wareham N. Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study. J Intern Med 2004;255:247-56.

Khaw K, Wareham N, Bingham S, Luben R, Welch A, Day N. Association of glycated hemoglobin with cardiovascular disease and mortality in adults: the EPIC-Norfolk prospective study. Ann Int Med 2004;141:413-20.

Khaw K, Bingham S, Welch A, Luben R, O'Brien E, Wareham N, Day N. Blood pressure and urinary sodium in men and women in the population: Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk). Am J Clin Nutr 2004;80:1397-1403.

Shohaimi S, Luben R, Wareham N, N Day, Bingham S, Welch A, Oakes S, Khaw K-T. Residential area deprivation predicts smoking habit independently of individual educational level and occupational social class. A cross sectional study in the Norfolk cohort of the European Investigation into Cancer (EPIC- Norfolk). J Epidemiol Community Health 2003; 57: 270-6.

Jakes R, Day N, Khaw K-T, Luben R, Oakes S, Welch A, Bingham S, Wareham N. Television viewing and low participation vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study. Eur J Clin Nutr 2003; 57 (9): 1089-96

Smith M, Kinmonth A, Luben R, Bingham S, Day N, Wareham N, Welch A, Khaw K-T. Smoking status and differential white cell count in men and women. Atherosclerosis 2003; 169: 331-7.

Jakes R, Day N, Patel B, Khaw K-T, Oakes S, Luben R, Welch A, Bingham S, Wareham N. Physical Inactivity is Associated with Lower Forced Expiratory Volume 1 Second European Prospective Investigation into Cancer-Norfolk Prospective Population Study. Am J Epidemiol 2002; 156: 139-147.

Wareham N, Jakes R, Rennie K, Mitchell J, Hennings S, Day N. Validity and repeatability of the EPEC-Norfolk Physical Activity Questionnaire. International Journal of Epidemiology 2002; 31: 168-174.

Luan J, Wong M, Day N, Wareham N. Sample size determination for studies of gene-environment interaction. International Journal of Epidemiology 2001; 30 :1035-1040

Sargeant L, Khaw K-T, Bingham S, Day N, Luben R, Oakes S, Welch A, Wareham N. Cigarette smoking glycaemia: the EPIC-Norfolk Study. International Journal of Epidemiology 2001; 30: 547-554

Sargeant L, Khaw K-T, Bingham S, Day N, Luben R, Oakes S, Welch A, Wareham N. Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study. European Journal of Clinical Nutrition 2001; 55: 342-348

Khaw K-T, Bingham S, Welch A, Luben R, Wareham N, Oakes S, Day N. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. Lancet 2001; 357: 657-663

Khaw K-T, Wareham N, Luben R, Bingham S, Oakes S, Welch A, Day N. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC - Norfolk). BMJ 2001; 322: 1-6

Bingham S, Welch A, McTaggart A, Mulligan A, Runswick S, Luben R, Oakes S, Khaw K-T, Wareham N, Day N. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk Public Health Nutrition 2001; 4(3): 847-858

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