South London Ethnicity and Stroke study

The aim of this study is to develop strategies to prevent strokes from occurring in African Caribbean people. People of this origin are twice as likely to have a stroke than Caucasian people. This study will try to find the reasons for this, which may include higher or unsuccessfully treated blood pressure and a greater risk of blood clotting. African Caribbean people may be more prone to strokes because of their genetic makeup, or a number of other factors. It has also been found that some types of stroke are more common in people of African Caribbean origin than others. These include intracerebral haemorrhage, which is bleeding into the brain substance, and lacunar stroke, which is a disease of the small vessels in the brain. If these factors were investigated it could lead to a decrease in the number of strokes, and the development of methods to prevent them.

PowerPoint presentation of this research project (147 kb)

This presentation was presented by the researchers at The Stroke Association Scientific Conference in September 2005.

Classification:
Prevention, Genetics, Ethnic Factors

Publications:

Jerrard-Dunne P, Sitzer M, Risley P, Buehler A, von Kegler S, Markus H. Inflammatory Gene Load is Associated with Enhanced Inflammation and Early Carotid Athereosclerosis in Smokers. Stroke, 2004;35:2438-2443.

Mackinnon A, Jerrard-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus H. Rates and Determinants of Site-Specific Progression of Carotid Artery Intima-Media Thickness. Stroke, 2004;35:2150-2154.

Jerrard-Dunne P, Stzer M, Risley P, Steckel DA, Buehler A, von Kegler S, Markus H. Interleukin-6 Promoter Polymorphism Modulates the Effects of Heavy Alcohol Consumption on Early Carotid Artery Atherosclerosis The Carotid Atherosclerosis Progression Study (CAPS). Stroke 2003; 34: 402-407.

Risley P, Jerrard-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus H. Promoter Polymorphism in the Endotoxin Receptor (CD14) Is Associated with Increased Carotid Atherosclerosis Only in Smokers. Stroke 2003; 34: 600-604.

Jerrard-Dunne P, Markus H, Steckel D, Buehler A, von Kegler S, Sitzer M. Early Carotid Atherosclerosis and Family History Vascular Disease: Special Effects on Arterial Sites Have Implicationsfor Genetic Studies. Stroke 2003; 23: 302-306.

Jerrard-Dunne P, Evans A, McGovern R, Hajat C, Kalra L, Rudd A, Wolfe C, Markus H. Ethnic Differences in Markers of Thrombophilia - Implications for the Investigation of Ischaemic Stroke in Multiethnic Populations: The South London Ethnicity and Stroke Study. Stoke 2003; 4:1821-1827.

Jerrard-Dunne P, Cloud G, Hassan A, Markus H. Evaluating the Genetic Component of Ischemic Stroke Subtypes. A Family History Study. Stroke 2003; 34: 1364 -1369.

Cloud G, Crawley F, Clifton A, McCabe D, Brown M, Markus H. Vertebral artery origin angioplasty and primary stenting:safety and restenosis rates in a prospective series. J Neurol Neurosurg Psychiatry 2003;74:586-590.

Markus H, Kapozsta Z, Ditrich R, Wolfe C, Ali N, Powell J, Mendell M, Cullinane M. Increased Common Carotid Intima-Media Thickness in UK African Caribbeans and Its Relation to Chronic Inflammation and Vascular Candidate Gene Polmorphisms. Stroke 2001; 32: 2465-2471.

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