Our Project Grants Awarded for 2016

Wednesday 11 January 2017

Project Grants are our most popular funding stream and cover the whole spectrum of stroke research - from prevention and risk factors, through to treatment and rehabilitation in a clinical setting and longer-term in the community.

To find out more about our project grants awarded for 2016, check out the summaries below.

Using a new human stem cell model to understand the causes of stroke and to test new treatments

Principal Investigator: Dr S Sinha 

Institution: University of Cambridge

CADASIL is one of the most common genetic causes of stroke and dementia. Currently, there's no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab. This work may pave the way for new treatments for CADASIL, and will allow us to better understand the ways that gene mutation causes disease.

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Can we better understand CVT, a type of stroke mainly affecting young women?

Principal Investigator: Professor Pankaj Sharma

Institution: Royal Holloway, University of London

Cerebral venous thrombosis (CVT) is an unusual form of stroke. It's little researched largely because it accounts for less than 1% of all strokes. The study will provide a much better understanding of the reasons underlying CVT, which is an unusual but very important cause of stroke in young (mainly female) adults. It could lead to a better prediction of who will have a CVT, as well as the discovery of specific treatments.

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Can a filter device protect the brain during stenting in the chest and reduce risk of stroke and brain injury?

Principal Investigator:  Mr R Gibbs

Institution: Imperial College London

Disease of the chest portion of the largest artery in the body (the aorta), is known as thoracic aortic disease (TAD). The number of people experiencing TAD is increasing. This study is investigating how to make thoracic endovascular aortic stenting (TEVAR), the preferred method of treating TAD, safer by using extra protection devices.

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Can a singing group help to improve wellbeing for people with post-stroke aphasia?

Principal Investigator: Dr Mark Tarrant

Institution: University of Exeter

Beyond impaired language function, people with aphasia report a range of psychosocial health problems which negatively affect their wellbeing, including reduced confidence and social isolation. These psychosocial problems are not adequately addressed by healthcare services. This study will pilot a new group-based singing intervention for improving the psychosocial health of people with aphasia.

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Delivering group support for people with aphasia through Eva Park

Principal Investigator: Professor Jane Marshall

Institution: City University London

About one third of stroke survivors acquire aphasia. This is a language disorder that disrupts the production and comprehension of speech, as well as reading and writing. This study will investigate whether a support group intervention can be delivered remotely to people with aphasia through a virtual island platform called Eva Park.

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A pilot study exploring a community walking programme using a metronome sound beat to improve stepping and daily activity following a stroke (ACTIVATE)

Principal Investigator: Dr Sara Moore

Institution: Newcastle University

As well as reducing independence, walking problems after stroke lead to lower daily activity, increasing risk of further stroke and health problems. A promising method of improving walking after stroke is through ‘auditory rhythmical cueing.’ which involves people walking to the rhythm of a sound beat. This method improves walking after stroke in the hospital, but has not been tested later on at home where recovery could continue.

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