CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab. This work may pave the way for new treatments for CADASIL, and will allow us to better understand the ways that gene mutation causes disease.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD. This project will bring together a multidisciplinary team to better understand apathy after SVD, and potential treatments.
Evaluation of a new test to detect cognitive impairment in patients with small vessel disease stroke
An investigation of whether functional strength training can improve the ability of stroke survivors to walk and use their arm and hand at least 1 year after stroke
The effect of cerebrospinal fluid drainage on brain oxygenation and haemodynamics after subarachnoid haemorrhage
Stroke Association/BHF Joint Programme Grant
The importance of variability in blood pressure after acute stroke
Using genetics to understand why disease of the small blood vessels in the brain occurs
Can training memory and attention on a home computer-task reduce spatial awareness problems after stroke?