Spatial neglect is caused when damage to the brain after stroke means that it no longer received information about one side of the body and/or world. Stroke survivors with spatial neglect might not be aware of anything happening on one side of their body. This research will investigate a computer based version of a new treatment for spatial neglect after stroke.
CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab. This work may pave the way for new treatments for CADASIL, and will allow us to better understand the ways that gene mutation causes disease.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD. This project will bring together a multidisciplinary team to better understand apathy after SVD, and potential treatments.
In this study, we are testing the theory that by treating BP more intensively we will delay progression of the disease. We will also use state-of-the-art MRI imaging techniques to look at the mechanisms by which any beneficial effect of BP occurs.
The importance of variability in blood pressure after acute stroke
Using genetics to understand why disease of the small blood vessels in the brain occurs.
Can training memory and attention on a home computer-task reduce spatial awareness problems after stroke?