Searching for medicines that can reduce damage after a bleed in the brain

University of Manchester
Status
Active
Summary

This research will investigate 2000 drugs that are already known to be safe for use in humans to see if they could help reduce the amount of damage to the brain an intracerebral haemorrhage (a type of stroke caused by a bleed in the brain) causes.

Date published
26/09/2019

Small Vessel Disease - Spotlight on Symptoms: using brain scans to find out which symptoms are linked to small vessel disease

University of Edinburgh
Status
Active
Summary

This project is part of a larger on-going study into Small Vessel Disease (SVD) after stroke. It will allow the researchers to invite some of the participants in this project back for more frequent brain scans and tests to help them to understand more about SVD after stroke.

Date published
26/09/2019

What causes swelling around strokes due to bleeding in the brain?

University of Edinburgh
Status
Active
Summary

People with stroke due to brain haemorrhage have swelling around the haemorrhage on their brain scan. More swelling worsens recovery. No treatment improves outcome after this swelling.

The programme will use biological information about cells and molecules, and information from patients, to design a study of treatment for swelling after brain haemorrhage.

Date published
01/04/2018

Can we transform stem cells to promote recovery after stroke?

University of Manchester
Status
Active
Summary

Inflammation is an important defence mechanism that the body uses in response to injury or infection. However, it can also be highly damaging to the brain directly after stroke. This study will investigate whether adult stem cells can be transformed and used to reduce inflammation in the brain after stroke, and promote recovey.

Date published
01/09/2017

Understanding and treating biological changes after a bleed in the brain

University of Manchester
Status
Active
Summary

Intracerebral haemorrhage (ICH) is a type of stroke, which is caused by bleeding in the brain, ultimately leading to brain damage, disability and often death. We currently know very little about the biological changes that occur in the brain after intracerebral haemorrhage. This research on ICH will use zebrafish models so that we can gain a much better understanding of how cells of the brain respond to the bleeding and if there are ways that we can stop the damage caused.

Date published
23/05/2017

Developing new models to better understand and allow testing of new therapies for small vessel disease and vascular dementia

University of Edinburgh
Status
Active
Summary

Small Vessel Disease (SVD) is a condition that affects the small blood vessels in the brain, and it can lead to stroke and dementia. This research programme hopes to increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.

Date published
20/05/2017

Failure of drainage of fluid from the brain along the walls of blood vessels in vascular dementia

University of Southampton
Status
Active
Summary

This project aims to demonstrate that failure of drainage of fluid from the grey and white matter of the brain is a mechanism underlying Small Vessel Disease, a condition that affects the small blood vessels in the brain which can cause stroke and dementia.

Date published
20/05/2017

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