University College London
Principal Investigator
Professor Alex Leff
Grant value
Research ID
TSA PDF 2017/02
Scientific title
Predicting recovery and treatment responses in post-stroke aphasia
Date published
Tuesday, 1 August, 2017

Postdoctoral fellowship

Awarded to Dr Tom Hope

Description of research

A stroke survivor's recovery from language difficulties is famously variable. Some stroke survivors respond better to treatments and recover much more quickly or more fully than others.

In recent years, one promising explanation of the variability in these patients’ recovery has begun to emerge. Different brain regions serve different functions, and it stands to reason that the consequences of stroke should depend on the details of the brain regions which are damaged or preserved. Using high-resolution brain imaging, those details can be measured, non-invasively, in very large samples of patients whose outcomes are already known. Dr Hope and the PLORAS researchers at UCL have previously shown that they can use this data to link better or worse language outcomes to the presence or absence of damage in particular brain regions. They can therefore predict reasonably accurate outcomes for new patients with language impairments.

The aim of the proposed work is to employ similar techniques to PLORAS to predict which patients are most suited to what speech and language therapy, which could then help them make a better recovery.


The fellowship will start 1 August 2017 for a duration of 36 months.