Scientific title:
Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomized trial of home telemetry-guided treatment (PROHIBIT-ICH)
University College London
Principal investigator:
Professor David Werring
Grant value:
Research ID:
TSA PPA 2015-04
Research area:
Start date:
Monday 10 October 2016
End date:
Tuesday 28 February 2023
6 years
Year awarded:


In the UK, around 150,000 people have a stroke every year, with up to 23,000 caused by bleeding in the brain, called intracerebral haemorrhage (ICH).

ICH is fatal in nearly 50% of cases, and survivors often have physical or memory and thinking (cognitive) problems, with a risk of further ICH and worsening cognition. Effective prevention of recurring ICH is therefore a key research goal.

ICH is usually due to a disease in the small blood vessels damaged by high blood pressure. Lowering blood pressure (BP) is the most promising way to prevent ICH, but many stroke survivors do not achieve good BP control. We don't know how lowering BP protects the brain, how much to lower it by, for how long, or how best to properly control it longer term. ‘Telemetric’ BP home monitoring looks very promising to control BP in minor stroke or transient ischaemic attack (TIA, “mini-stroke”), but has not been tested in survivors of ICH, who have more disability, or at multiple hospital centres.

About the research

In this study, 100 ICH survivors will be randomly allocated to either home BP monitoring using telemetry (sending BP information to a study coordinating centre) to allow treatment adjustments to improve BP control; or to standard care. MRI scans of the brain will be taken to see whether intensive BP treatment reduces brain injury over time, assessed by the build-up of new, tiny areas of bleeding (cerebral microbleeds).

What difference could this research make?

This study could show whether more intensive lowering of BP in survivors of ICH is possible, safe and effective in reducing brain injury. If successful, a larger definitive trial may be designed. The intervention should allow survivors of ICH to know, understand and manage their own BP to prevent strokes and cognitive impairment and improve outcomes.

Professor David Werring was awarded the 'Stroke Association - The Lord Leonard and Lady Estelle Wolfson Foundation Priority Programme Award' in 2016. David is pictured below (centre) receiving this award from Lady Estelle Wolfson and Professor Sir Mark Wolport at our 2016 Keynote Lecture.

Professor David Werring receiving his award