This fellowship will involve the study of the human eye to find out about the health of the brain’s small blood vessels and nerve connections in people who have recently had a stroke.
The overall purpose of this research is to make laboratory stroke experiments more reliable and useful for informing how to design human clinical trials with a higher chance of success.
This research project aims to better understand how particular features of the CT scan can be used to make better treatment decisions for patients with ischaemic stroke, and whether we can accurately estimate the time since the stroke began.
People with stroke due to brain haemorrhage have swelling around the haemorrhage on their brain scan. More swelling worsens recovery. No treatment improves outcome after this swelling.
The programme will use biological information about cells and molecules, and information from patients, to design a study of treatment for swelling after brain haemorrhage.
This study will investigate whether early initiation of direct anticoagulant drugs will be as safe as later initiation in stroke patients with an abnormal heart rhythm (atrial fibrillation). It will also investigate whether early initation could lead to fewer recurrent strokes.
The aim of this research programme is to develop a human brain bank to support biomedical research into the pathophysiology of human SVD that may be used nationally and internationally.
Magnetic resonance imaging (MRI) scans provide lots of data on the health of a person’s brain, not all of which is routinely used in clinical practice. This project will continue the development of tools to assess the brain scans of people with stroke. The outcome of this research should produce methods that can predict how patients will fare after a stroke, helping doctors to decide the best treatments and improve outcomes.
Following a stroke, many treatments are recommended by health professionals, such as medications to prevent another stroke or physiotherapy to help limb weakness. Stroke survivors often have other chronic illnesses and report finding it difficult to follow treatments recommended by their doctors, nurses and therapists. This project aims to develop a way of measuring the workload and potential difficulties encountered by those who have had a stroke when managing their health problems, and aims to develop and test possible solutions.
A collaboration of experts in stroke and vascular dementia has worked with people affected by both diseases to create a program of work that answers fundamental questions: who will develop memory and thinking problems after stroke, why does this happen, how can we treat it?
This research programme could substantially increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.