This study will show whether more intensive lowering of blood pressure (BP) in survivors of intracerebral haemorrhage (ICH) is feasible, safe and effective in reducing brain injury. If successful, the study will pave the way for the design a larger definitive trial.
Problems of mood, thinking and memory are common after a stroke. There has been limited research around these issues. This work aims to answer fundamental questions around who develops these problems and how they recover.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD. This project will bring together a multidisciplinary team to better understand apathy after SVD, and potential treatments.
Most stroke and transient ischaemic attack (TIA) survivors are asked to take medicines, which some can find difficult. However, taking the medicines prescribed after a stroke, or TIA, and following lifestyle advice can reduce the chance of another stroke by 80%. Unfortunately, over 25% of stroke survivors do not continue these medicines, even for the first year after their stroke. Another 20% take less than is needed for the medicines to work.
This research will use the views of stroke and TIA survivors to design a life-long medicines support service which could be provided by pharmacists.
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2) - TSA BHF 2015/01
Up to 70% of stroke survivors complain of tiredness or fatigue, sometimes years after stroke. Unlike normal tiredness, post stroke fatigue does not always respond to rest. The cause of extreme tiredness is not known and there are no definitive treatments available. This research investigates the use of non-invasive brain stimulation to see whether low 'excitability' of the brain causes fatigue after stroke.
Postdoctoral Fellow: Dr Ulrike Hammerbeck (TSA PDF 2015-02)
Postgraduate Fellow: Mr Graham McClelland (TSA PGF 2015-01)
Postgraduate Fellowship: Ms Emma Pilkington (TSA PGF 2015-02)