The aim of this study is to develop a fatigue management programme to improve stroke survivors' knowledge of post stroke fatigue (PSF) and to identify ways of managing it.
CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab. This work may pave the way for new treatments for CADASIL, and will allow us to better understand the ways that gene mutation causes disease.
This project aims to find out if peer support can avert some of the adverse psychological consequences of aphasia, the language and communication disorder that affects about 15% of those who have a stroke. Stroke survivors with long-term aphasia will be trained as peer befrienders. They will be paired with individuals with aphasia who have had more recent strokes, e.g. to offer conversation, help with problem solving and social activities.
Early Supported Discharge (ESD) is the discharge of a stroke patient from hospital to their own home, co-ordinated by a team of therapists, nurses and a doctor. A number of ESD services have been set up across England. Do these services offer the same benefits to patients as those identified in clinical trials?
Stroke survivors often have very individual hopes for the future, in terms of the goals they would like to achieve. This research will develop and test a Goal setting and Action Planning (G-AP) approach to achieving personal goals through community rehabilitation.
Problems of mood, thinking and memory are common after a stroke. There has been limited research around these issues. This work aims to answer fundamental questions around who develops these problems and how they recover.
This study will show whether more intensive lowering of blood pressure (BP) in survivors of intracerebral haemorrhage (ICH) is feasible, safe and effective in reducing brain injury. If successful, the study will pave the way for the design a larger definitive trial.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD. This project will bring together a multidisciplinary team to better understand apathy after SVD, and potential treatments.
Most stroke and transient ischaemic attack (TIA) survivors are asked to take medicines, which some can find difficult. However, taking the medicines prescribed after a stroke, or TIA, and following lifestyle advice can reduce the chance of another stroke by 80%. Unfortunately, over 25% of stroke survivors do not continue these medicines, even for the first year after their stroke. Another 20% take less than is needed for the medicines to work.
This research will use the views of stroke and TIA survivors to design a life-long medicines support service which could be provided by pharmacists.