About 80% of strokes are caused by a blocked blood vessel. One third of these patients have a blockage of a large blood vessel in the neck or brain known as large artery occlusion stroke (LAOS).
Intracerebral haemorrhage (ICH) is a type of stroke, which is caused by bleeding in the brain, ultimately leading to brain damage, disability and often death. We currently know very little about the biological changes that occur in the brain after intracerebral haemorrhage.
This project is part of a larger on-going study into Small Vessel Disease (SVD) after stroke. It will allow the researchers to invite some of the participants in this project back for more frequent brain scans and tests to help them to understand more about SVD after stroke.
Co-funded by the Stroke Association, the only project of its kind anywhere that studies all acute vascular events, such as strokes and heart attacks, to develop better treatments has recruited its 10,000th Oxfordshire participant.
Pilot trial of devices to extract clot from occluded arteries (PISTE)
This project aims to demonstrate that failure of drainage of fluid from the grey and white matter of the brain is a mechanism underlying Small Vessel Disease, a condition that affects the small blood vessels in the brain which can cause stroke and dementia.
Small Vessel Disease (SVD) is a condition that affects the small blood vessels in the brain, and it can lead to stroke and dementia. This research programme hopes to increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.
In this study, we are testing the theory that by treating BP more intensively we will delay progression of the disease. We will also use state-of-the-art MRI imaging techniques to look at the mechanisms by which any beneficial effect of BP occurs.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD.