Using genetics to understand why disease of the small blood vessels in the brain occurs.
Can using a tissue sample from the buttock help us understand the main genetic cause of stroke?
Researchers at King's College London have performed a large scale meta-analysis of previous research into a genetic variant of a protein implicated in stroke.
CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab.
These summaries of our completed research projects highlight what work was undertaken, which aims were achieved and where the research is going next.
Cerebral venous thrombosis (CVT) is an unusual form of stroke. It is little researched largely because it accounts for less than 1% of all strokes. The study will provide a much better understanding for the reasons underlying CVT, which is an unusual but very important cause of stroke in young (mainly female) adults.
Developing new blood tests to understand more about children with sickle cell anaemia and silent strokes.
This programme of work had been created by experts in stroke and vascular dementia working with people affected by both conditions. This research programme aims to find out who will develop memory and thinking problems after stroke, why this happens, and how we can treat these issues.
This project aims to demonstrate that failure of drainage of fluid from the grey and white matter of the brain is a mechanism underlying Small Vessel Disease, a condition that affects the small blood vessels in the brain which can cause stroke and dementia.
The aim of this research programme is to develop a human brain bank to support biomedical research into the pathophysiology of human SVD that may be used nationally and internationally.