This study will investigate whether reducing blood pressure can stop bleeding in the brain after thrombolysis (a clot-busting treatment for stroke) and improve patient's outcomes.
Stroke survivors and healthcare professionals have identified problems with thinking and mood after stroke as some of the most important issues faced after a stroke. This Lectureship aims to test treatments to help stroke survivors with their cognitive (thinking) difficulties.
The overall purpose of this research is to make laboratory stroke experiments more reliable and useful for informing how to design human clinical trials with a higher chance of success.
Improving our prediction of recovering language abilities after stroke.
Up to 70% of stroke survivors complain of tiredness or fatigue, sometimes years after stroke. Unlike normal tiredness, post stroke fatigue does not always respond to rest. The cause of extreme tiredness is not known and there are no definitive treatments available.
The recovery of stroke survivors with language difficulties is famously variable. Some stroke survivors recover much more quickly or fully than others. Some respond to treatment much better than others.
Thrombolysis, where drugs are injected into the blood to break up a blood clot, is one of the main treatments used to treat people who are having a stroke caused by a clot. Currently a drug called alteplase is used in thrombolysis. But the researchers think that another drug, called tenecteplase, may be more effective than alteplase. This study will investigate if this is the case.
Pilot trial of devices to extract clot from occluded arteries (PISTE)
This study will test arm training to encourage a functionally useful contribution to recovery from the side of the brain unaffected by stroke (the 'non-stroke hemisphere'), and whether this is only possible early after stroke.
Can an anti-inflammatory drug (IL-1Ra) given into the skin reduce damaging inflammation in the brain and body after stroke compared to a dummy-drug?