The aim of this research programme is to develop a human brain bank to support biomedical research into the pathophysiology of human SVD that may be used nationally and internationally.
Using genetics to understand why disease of the small blood vessels in the brain occurs
If we are to discover which underlying genes cause stroke, we need to collect DNA from large numbers of patients who have had a lacunar stroke. An existing collection of DNA (extracted from blood samples) from patients has been established with the aid of a Wellcome Trust grant, this is called the UK Young Lacunar Stroke DNA Database.
This project is part of a larger on-going study into Small Vessel Disease (SVD) after stroke. It will allow the researchers to invite some of the participants in this project back for more frequent brain scans and tests to help them to understand more about SVD after stroke.
In this study we are testing the theory that by treating BP more intensively we will delay progression of the disease. We will also use state-of-the-art MRI imaging techniques to look at the mechanisms by which any beneficial effect of BP occurs.
This research programme could substantially increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.
This research is focused on assessing the relationship between the variability of the blood flow through the blood vessels supplying the brain, and the risk of stroke in patients who have already had a stroke or “mini-stroke” (TIA) in the past.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD.
TSA LECT 2015/04 Dr Fergus Doubal, University of Edinburgh
Professor Joanna Wardlaw CBE talks about the new SVDs@target programme - Targeting interventions for small vessel disease to prevent stroke and dementia. This programme was funded by a 6 million euro grant from the European Union’s Horizon 2020 programme.