The aim of this research programme is to develop a human brain bank to support biomedical research into the pathophysiology of human SVD that may be used nationally and internationally.
Using genetics to understand why disease of the small blood vessels in the brain occurs.
This project is part of a larger on-going study into Small Vessel Disease (SVD) after stroke. It will allow the researchers to invite some of the participants in this project back for more frequent brain scans and tests to help them to understand more about SVD after stroke.
Professor Joanna Wardlaw CBE talks about the new SVDs@target programme - Targeting interventions for small vessel disease to prevent stroke and dementia. This programme was funded by a 6 million euro grant from the European Union’s Horizon 2020 programme.
Small Vessel Disease (SVD) is a condition that affects the small blood vessels in the brain, and it can lead to stroke and dementia. This research programme hopes to increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.
In this study, we are testing the theory that by treating BP more intensively we will delay progression of the disease. We will also use state-of-the-art MRI imaging techniques to look at the mechanisms by which any beneficial effect of BP occurs.
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD.
This research is focused on assessing the relationship between the variability of the blood flow through the blood vessels supplying the brain, and the risk of stroke in patients who have already had a stroke or “mini-stroke” (TIA) in the past.
Small Vessel Disease (SVD) is a disease of the small blood vessels in the brain and can lead to stroke and dementia. At the moment, we don't know how to stop SVD developing, or how to treat it. This Lectureship aims to improve future clinical trials that aim to prevent SVD.
This fellowship will involve the study of the human eye to find out about the health of the brain’s small blood vessels and nerve connections in people who have recently had a stroke.