Developing new blood tests to understand more about children with sickle cell anaemia and silent strokes
Stroke can happen to anyone, including children. The causes of stroke for children are very different from those for adults. This guide explains what can cause stroke in children and how it is treated.
If you are of African or Caribbean origin you may have a higher risk of stroke than other people in the UK due to health conditions such as high blood presure, diabetes and sickle cell disease. This guide explains more about your risk of a stroke, and what you can do to reduce your risk.
Intracerebral haemorrhage (ICH) is a type of stroke, which is caused by bleeding in the brain, ultimately leading to brain damage, disability and often death. We currently know very little about the biological changes that occur in the brain after intracerebral haemorrhage.
Inflammation is an important defence mechanism that the body uses in response to injury or infection. However, it can also be highly damaging to the brain directly after stroke. This study will investigate whether adult stem cells can be transformed and used to reduce inflammation in the brain after stroke, and promote recovey.
CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab.
This research programme could substantially increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.
Using genetics to understand why disease of the small blood vessels in the brain occurs
Most strokes happen because of a blockage in an artery. A common cause of this is disease in the large carotid arteries in the front of your neck. This guide explains what can cause carotid artery disease and how it can be treated.
The aim of this research programme is to develop a human brain bank to support biomedical research into the pathophysiology of human SVD that may be used nationally and internationally.