Developing new blood tests to understand more about children with sickle cell anaemia and silent strokes
Inflammation is an important defence mechanism that the body uses in response to injury or infection. However, it can also be highly damaging to the brain directly after stroke. This study will investigate whether adult stem cells can be transformed and used to reduce inflammation in the brain after stroke, and promote recovey.
CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab.
This research programme could substantially increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.
Published in the journal, The Lancet, the findings of the PISCES I study shed more light on the potential use of stem cell treatment for stroke.
Dr Shamim Quadir, Research Communications Manager at the Stroke Association comments.
Published in the medical journal Stroke, a new US study suggests that treatment of chronic stroke patients with injections of modified, adult stem cells into their brains is safe, and could lead to recovery of movement that was originally lost due to stroke.
Co-funded by the Stroke Association, the only project of its kind anywhere that studies all acute vascular events, such as strokes and heart attacks, to develop better treatments has recruited its 10,000th Oxfordshire participant.
Thousands of lives a year could be changed thanks to a pilot research study by Imperial College which involves injecting a patient's stem cells into their brain.
Do Naturally Produced Cells in the Brain Contribute to Repairing the Damage Done by Stroke?
The effect of blood pigments on brain inflammation and survival of nerve cells