Around 15% of strokes are haemorrhagic (due to bleeding in or around the brain). This guide explains the two different types of stroke caused by a bleed, intracerebral and subarachnoid haemorrhage, and how they are diagnosed and treated.
Cerebral venous thrombosis (CVT) is an unusual form of stroke. It is little researched largely because it accounts for less than 1% of all strokes. The study will provide a much better understanding for the reasons underlying CVT, which is an unusual but very important cause of stroke in young (mainly female) adults.
In this project, the aim is to demonstrate that failure of drainage of fluid from the grey and white matter of the brain is a mechanism underlying SVD.
People with stroke due to brain haemorrhage have swelling around the haemorrhage on their brain scan. More swelling worsens recovery. No treatment improves outcome after this swelling.
The programme will use biological information about cells and molecules, and information from patients, to design a study of treatment for swelling after brain haemorrhage.
Using genetics to understand why disease of the small blood vessels in the brain occurs
The effect of cerebrospinal fluid drainage on brain oxygenation and haemodynamics after subarachnoid haemorrhage
Cerebral small vessel disease (SVD) is usually associated with high blood pressure, and causes 20% of all strokes. It is the main cause of cognitive changes and dementia associated with stroke. Behavioural symptoms such as apathy are also common in patients with SVD.
Disease of the chest portion of the largest artery in the body (the aorta), is known as thoracic aortic disease (TAD). The number of people experiencing TAD is increasing. This study is investigating how to make thoracic endovascular aortic stenting (TEVAR), the preferred method of treating TAD, safer by using extra protection devices.
Developing new blood tests to understand more about children with sickle cell anaemia and silent strokes
This research programme could substantially increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.