Developing new blood tests to understand more about children with sickle cell anaemia and silent strokes
Intracerebral haemorrhage (ICH) is a type of stroke, which is caused by bleeding in the brain, ultimately leading to brain damage, disability and often death. We currently know very little about the biological changes that occur in the brain after intracerebral haemorrhage.
CADASIL is one of the most common genetic causes of stroke and dementia. Currently there is no treatment for CADASIL. In this study, human stem cells will be generated from a piece of skin donated by patients with CADASIL. From these stem cells, smooth muscle cells (SMCs) will be generated in a tissue culture dish in the lab.
Inflammation is an important defence mechanism that the body uses in response to injury or infection. However, it can also be highly damaging to the brain directly after stroke. This study will investigate whether adult stem cells can be transformed and used to reduce inflammation in the brain after stroke, and promote recovey.
This research programme could substantially increase our understanding of how SVD develops, leading to new ways to investigate SVD and test drugs which may help treat it.
Using genetics to understand why disease of the small blood vessels in the brain occurs
The aim of this research programme is to develop a human brain bank to support biomedical research into the pathophysiology of human SVD that may be used nationally and internationally.
The effect of blood pigments on brain inflammation and survival of nerve cells
Published in the journal, The Lancet, the findings of the PISCES I study shed more light on the potential use of stem cell treatment for stroke.
Dr Shamim Quadir, Research Communications Manager at the Stroke Association comments.