University of Glasgow
Scientific title
Xanithine oxidase Inhibition for improvement of Long-term Outcomes Following Ischaemic Stroke and Transient ischaemic attack (XILO-FIST)
Principal Investigator
Professor Jesse Dawson
Year awarded
Grant value
Research ID
TSA BHF 2013-01
Research area
Start date
Monday 17 March 2014
End date
Saturday 17 October 2020
60 months


Allopurinol is a type of drug called a ‘xanithine oxidase inhibitor’. Allopurinol is used to prevent gout, a condition where salt crystals build up within a joint, causing pain and swelling. 

Allopurinol has also shown promise as a drug to reduce stroke risk. It has been shown to reduce a number of cardiovascular risk factors which can lead to stroke. These risk factors are also indicators of scars building up on the brain, called white matter hyper-intensities (WHM). Such WHM appear around the site of a stroke in about 90% of all strokes where blood clots block blood flow to the brain (ischaemic stroke). Critically, WHM are predictive of future stroke, dementia, and cognitive decline.


In the current study, 464 stroke survivors will take part for two years. Over this time, half of them will receive 300mg of allopurinol twice daily, and the other half will receive an equivalent ‘dummy’ drug.

At the beginning and end of the study, all participants will have a brain scan to compare changes in levels of WHM brain scarring between the allopurinol and the dummy-drug groups. Eligible participants will also form sub-groups to additionally test for heart muscle thickness and blood pressure – both stroke risk factors.

If the study finds that allopurinol has a beneficial effect on stroke survivors, it would promptly be followed up by a larger, worldwide study to confirm the benefit.