Stroke survivors and their relatives consistently ask for information about how much recovery can be expected. This study will look at how well a patient can use their arm after stroke, and at their brain images recorded within 72-hours after stroke. The hope is that brain images can improve our prediction of patient arm movement recovery at six months after stroke.
Although speech and language therapists (SLTs) may help aphasia patients with their rehabilitation, there remains a clear lack of evidence-based treatments available for them to help their patients with problems of everyday talking, known as ‘discourse’. This study aims to address both the need for evidence-based treatments and improvement of clinical expertise to address discourse problems after stroke.
The recovery of stroke survivors with language difficulties is famously variable. Some stroke survivors recover much more quickly or fully than others. Some respond to treatment much better than others. The aim of the proposed work is to employ similar techniques to PLORAS project to predict which patients are most suited to what speech and language therapy, which could then help them make their best recovery.
Disease of the chest portion of the largest artery in the body (the aorta), is known as thoracic aortic disease (TAD). The number of people experiencing TAD is increasing. This study is investigating how to make thoracic endovascular aortic stenting (TEVAR), the preferred method of treating TAD, safer by using extra protection devices.
About one third of stroke survivors are left with aphasia. This is a language disorder that disrupts the production and comprehension of speech, as well as reading and writing. This study will investigate whether a support group intervention can be delivered remotely to people with aphasia through a virtual island platform called Eva Park.
This study will explore whether an existing therapy, Solution Focused Brief Therapy (SFBT), can be used for people with aphasia. Information will also be collected to design a future large-scale trial evaluating this approach.
This project aims to find out if peer support can avert some of the adverse psychological consequences of aphasia, the language and communication disorder that affects about 15% of those who have a stroke. Stroke survivors with long-term aphasia will be trained as peer befrienders. They will be paired with individuals with aphasia who have had more recent strokes, e.g. to offer conversation, help with problem solving and social activities.
This study will show whether more intensive lowering of blood pressure (BP) in survivors of intracerebral haemorrhage (ICH) is feasible, safe and effective in reducing brain injury. If successful, the study will pave the way for the design a larger definitive trial.
Up to 70% of stroke survivors complain of tiredness or fatigue, sometimes years after stroke. Unlike normal tiredness, post stroke fatigue does not always respond to rest. The cause of extreme tiredness is not known and there are no definitive treatments available. This research investigates the use of non-invasive brain stimulation to see whether low 'excitability' of the brain causes fatigue after stroke.
In stroke survivors, does the clinical effectiveness of 6 months treatment with fluoxetine depend upon its effects on synaptic plasticity in the brain? Can a drug used for depression help stroke recovery by changing connections between brain cells?